At Sergio Pablos Animation, I was the Computer Graphics Supervisor on the Traditional 2D Film "Ember" for a few months until the film was cancelled.
We were in the process of designing a Blender Geometry Node based environment system that would allow us the flexibility to use 3D assets along with painted elements to build out sets. We created custom shaders with stylized light terminators to match concept art such as the piece above by Szymon Biernacki.
Apart from this, several other systems were being used, including a rigged character layout system, and a 3D-to-Layers environment baking system.